反应详情

1.22 g (3.61 mmol) of ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate (synthesis analogous to Example 4A, stage 3, or else according to Tetrahedron Lett. 2003, 44, 1607 and literature cited therein) in 50 ml of THF are mixed with 1.46 g (7.21 mmol) of 4-(trifluoromethoxy)phenyl isocyanate under argon and stirred at room temperature overnight. The reaction mixture is filtered, and the filtrate is concentrated in vacuo and purified by chromatography.

1. filtrationThe reaction mixture is filtered
2. concentrationthe filtrate is concentrated in vacuo
3. custompurified by chromatography