反应详情

To a solution of 6-(2′-hydroxy-3′-phenyl-5′-tert-butylphenyl)-2-formyl-pyridine (12) (3.17 g, 9.17 mmol) in the minimum volume of methanol was added 2,6-diisopropylaniline (1.79 g, 10.1 mmol). After the addition of a few drops of formic acid, the solution was stirred overnight. The cloudy yellow reaction mixture was then filtered through a frit, and the solid washed with methanol (3×5 mL), giving compound 13 as a yellow solid. Yield: 2.92 g (65%).

1. filtrationThe cloudy yellow reaction mixture was then filtered through a frit
2. washthe solid washed with methanol (3×5 mL)