1-Methylimidazole → Silane, (2,2-dimethylpropoxy)trimethyl-

HRID 500045Notes

Reaction equation

HRID 500045 reaction equation
Cl[Si:2]([CH3:5])([CH3:4])[CH3:3].[CH2:6]([OH:11])[C:7]([CH3:10])([CH3:9])[CH3:8].CN1C=CN=C1>>[CH3:8][C:7]([CH3:10])([CH3:9])[CH2:6][O:11][Si:2]([CH3:5])([CH3:4])[CH3:3]

Participants

4

Reactant 3

HCID 13901-MethylimidazoleHCID 6397ChlorotrimethylsilaneHCID 6404Neopentyl alcohol

Product 1

HCID 552401Silane, (2,2-dimethylpropoxy)trimethyl-Yield 85.8%

Conditions

Temperature
0 °C

Procedure

6.50 g (56.7 mmol) of chlorotrimethylsilane were added dropwise to a solution of 5.00 g (56.7 mmol) of neopentyl alcohol (2,2-dimethyl-1-propanol) and 11.6 g (142 mmol) of 1-methylimidazole while stirring at 0° C. The reaction mixture was stirred for a further 2 hours at 0° C. and for 2.5 hours at 20° C. The upper phase was separated off to give 7.80 g (theory: 9.09 g) of 2,2-dimethyl-1-trimethylsilyloxypropane as a colorless oil having a purity of 96% (GC).

Workup

  1. stirringThe reaction mixture was stirred for a further 2 hours at 0° C. and for 2.5 hours at 20° C
  2. customThe upper phase was separated off

Sources & evidence

ORD record
ord-64f1ee2312804dd68b8c915af2893522
Source dataset
uspto-grants-2010_08
Patent number
US07767852B2

Reaction notes

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