HCID 178491613, compound → HCID 178491614, compound

HRID 500089Notes

Reaction equation

HRID 500089 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([NH:11][C@H:12]2[CH2:17][CH2:16][C@@H:15]([CH:18]=[C:19]([CH3:21])[CH3:20])[CH2:14][CH2:13]2)=[O:10])=[CH:4][C:3]=1[O:22][CH3:23]>C(O)C.[Pt]=O>[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([NH:11][C@H:12]2[CH2:17][CH2:16][C@@H:15]([CH2:18][CH:19]([CH3:21])[CH3:20])[CH2:14][CH2:13]2)=[O:10])=[CH:4][C:3]=1[O:22][CH3:23]

Participants

4

Reactant 1

HCID 178491613HCID 178491613, compound

Product 1

HCID 178491614HCID 178491614, compoundYield 69.6%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 702EthanolSolvent

Procedure

The compound (0.3 g) of Example 95 was dissolved in ethanol (15 ml), platinum oxide (50 mg) was added to the solution, and the mixture was hydrogenated at room temperature. After 3 hours, the catalyst was removed by filtration from the reaction mixture and then the solvent was evaporated under reduced pressure. The residue was crystallized from diisopropyl ether to give 0.21 g of the desired compound.

Workup

  1. customwas hydrogenated at room temperature
  2. customthe catalyst was removed by filtration from the reaction mixture
  3. customthe solvent was evaporated under reduced pressure
  4. customThe residue was crystallized from diisopropyl ether

Sources & evidence

ORD record
ord-eb862bff5f08455fbf70e0df936fc198
Source dataset
uspto-grants-2010_08
Patent number
US07767854B2

Reaction notes

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