Ammonia → 6-(4-Fluorophenyl)-1,2,4-triazin-3-amine

HRID 500106Notes

Reaction equation

HRID 500106 reaction equation
[NH3:1].Cl[C:3]1[N:4]=[N:5][C:6]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)=[CH:7][N:8]=1>O1CCCC1>[F:15][C:12]1[CH:13]=[CH:14][C:9]([C:6]2[N:5]=[N:4][C:3]([NH2:1])=[N:8][CH:7]=2)=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 213152193-Chloro-6-(4-fluorophenyl)-1,2,4-triazine

Product 1

HCID 672240676-(4-Fluorophenyl)-1,2,4-triazin-3-amine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
50 °C

Procedure

Ammonia gas was bubbled through a solution of 3-chloro-6-(4-fluorophenyl)-1,2,4-triazine (600 mg, 0.0029 mol) in tetrahydrofuran (8 mL) for 5 min at −40° C. The reaction mixture was sealed and heated at 50° C. for 2 hours. The mixture was concentrated under reduced pressure to yield the desired product (550 mg) which was directly used in the next step without further purification. LCMS: (M+H)=209.1.

Workup

  1. customThe reaction mixture was sealed
  2. concentrationThe mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-241f60c201cd4ffcb46cc022d1a70bcd
Source dataset
uspto-grants-2010_08
Patent number
US07767675B2

Reaction notes

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