Hydrochloric Acid → 1029715-20-5

HRID 500166Notes

Reaction equation

HRID 500166 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH2:11][CH2:10][CH:9]([NH:12]C(=O)OC(C)(C)C)[CH2:8]1.[ClH:20]>CO.O1CCOCC1>[ClH:20].[ClH:20].[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[N:7]1[CH2:11][CH2:10][CH:9]([NH2:12])[CH2:8]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67019304HCID 67019304, compound

Product 1

HCID 670193811029715-20-5Yield 92%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl (1-pyridin-2-ylpyrrolidin-3-yl)carbamate (2.5 g) was dissolved in methanol (4 mL) and was treated with 4M hydrogen chloride in 1,4-dioxane (8 mL). The mixture was stirred overnight at RT. The solvents were evaporated under reduced pressure. The residue was washed with ether and dried to give the desired product (2.1 g, 92%). LCMS: (M+H)=164.1.

Workup

  1. customThe solvents were evaporated under reduced pressure
  2. washThe residue was washed with ether
  3. customdried

Sources & evidence

ORD record
ord-476bc1987be0473ebb4dc6eab7e1ef5f
Source dataset
uspto-grants-2010_08
Patent number
US07767675B2

Reaction notes

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