反应详情

温度

85 °C

A reaction mixture of N-[4-chloro-3-(3-methyl-2-butenyloxy)phenyl]-2-methyl-3-furancarboxamide (4 g), sodium bicarbonate (7.4 g) and Lawesson's reagent (3.6 g) in toluene (168 mL) was gradually heated to 85° C. over 1½ hours and then held at this temperature for a further 2½ hours. The reaction mixture was then cooled and filtered through a plug of neutral aluminum oxide and eluted with ether:petroleum ether (1:1). Evaporation of the solvent gave the product, N-[4-chloro-3-(3-methyl-2-butenyloxy)phenyl]-2-methyl-3-furancarbothioamide, 2.6 g.

1. waitheld at this temperature for a further 2½ hours
2. temperatureThe reaction mixture was then cooled
3. filtrationfiltered through a plug of neutral aluminum oxide
4. washeluted with ether:petroleum ether (1:1)
5. customEvaporation of the solvent