Lithium Hydroxide → HCID 67223924, compound

HRID 500194Notes

Reaction equation

HRID 500194 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[C:12]1[CH:13]=[N:14][C:15]2[N:16]([C:18]([C:21]3([C:24]4[CH:25]=[C:26]5[C:31](=[CH:32][CH:33]=4)[N:30]=[CH:29][CH:28]=[CH:27]5)[CH2:23][CH2:22]3)=[CH:19][N:20]=2)[CH:17]=1)[C:5]([O:7]C)=[O:6].[OH-].[Li+]>C1COCC1.CO.O.O>[F:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[C:12]1[CH:13]=[N:14][C:15]2[N:16]([C:18]([C:21]3([C:24]4[CH:25]=[C:26]5[C:31](=[CH:32][CH:33]=4)[N:30]=[CH:29][CH:28]=[CH:27]5)[CH2:23][CH2:22]3)=[CH:19][N:20]=2)[CH:17]=1)[C:5]([OH:7])=[O:6]

Participants

5

Reactant 2

HCID 3939Lithium HydroxideHCID 67223734HCID 67223734, compound

Product 1

HCID 67223924HCID 67223924, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 21892291Methanol tetrahydrofuran waterSolvent

Conditions

Temperature
0 °C

Procedure

To a solution of methyl 3-fluoro-4-[3-(1-quinolin-6-ylcyclopropyl)imidazo[1,2-a]pyrimidin-6-yl]benzoate (100 mg, 0.2 mmol) in 5 ml of THF-MeOH—H2O (3:1:1) was added 2M of lithium hydroxide in water (0.23 mL) at 0° C. under N2. The solution was stirred for 10 min at 0° C., and 1.5 h at RT. The reaction solution was concentrated to dryness to give the desired product which was directly used in next step without further purification.

Workup

  1. custom1.5 h
  2. customat RT
  3. concentrationThe reaction solution was concentrated to dryness

Sources & evidence

ORD record
ord-7849281f854f406ba5f79d53ee5e363f
Source dataset
uspto-grants-2010_08
Patent number
US07767675B2

Reaction notes

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