Trifluoroacetic acid → 5-{2-Fluoro-4-[3-(1-quinolin-6-ylcyclopropyl)imidazo[1,2-a]pyrimidin-6-yl]phenyl}-N,N-dimethylpyridine-2-carboxamide

HRID 500202Notes

Reaction equation

HRID 500202 reaction equation
[C:1](O)([C:3](F)(F)F)=[O:2].Br[C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:16]=[N:17][C:18]3[N:19]([C:21]([C:24]4([C:27]5[CH:28]=[C:29]6[C:34](=[CH:35][CH:36]=5)[N:33]=[CH:32][CH:31]=[CH:30]6)[CH2:26][CH2:25]4)=[CH:22][N:23]=3)[CH:20]=2)=[CH:11][C:10]=1[F:37]>>[F:37][C:10]1[CH:11]=[C:12]([C:15]2[CH:16]=[N:17][C:18]3[N:19]([C:21]([C:24]4([C:27]5[CH:28]=[C:29]6[C:34](=[CH:35][CH:36]=5)[N:33]=[CH:32][CH:31]=[CH:30]6)[CH2:26][CH2:25]4)=[CH:22][N:23]=3)[CH:20]=2)[CH:13]=[CH:14][C:9]=1[C:15]1[CH:12]=[CH:11][C:3]([C:1]([N:19]([CH3:20])[CH3:18])=[O:2])=[N:17][CH:16]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 672251686-{1-[6-(4-Bromo-3-fluorophenyl)imidazo[1,2-a]pyrimidin-3-yl]cyclopropyl}quinoline

Product 1

HCID 251455155-{2-Fluoro-4-[3-(1-quinolin-6-ylcyclopropyl)imidazo[1,2-a]pyrimidin-6-yl]phenyl}-N,N-dimethylpyridine-2-carboxamide

Procedure

This compound was prepared as a TFA salt starting from 6-{1-[6-(4-bromo-3-fluorophenyl)imidazo[1,2-a]pyrimidin-3-yl]cyclopropyl}quinoline using procedures analogous to those for Example 85. LCMS: (M+H)=529.0.

Sources & evidence

ORD record
ord-3daa6da049b14dd1bad6532503c9ee57
Source dataset
uspto-grants-2010_08
Patent number
US07767675B2

Reaction notes

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