Trifluoroacetic acid → HCID 59420909, compound

HRID 500212Notes

Reaction equation

[C:1](O)([C:3](F)(F)F)=[O:2].Br[C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:16]=[N:17][C:18]3[N:19]([C:21]([C:24]4([C:27]5[CH:28]=[C:29]6[C:34](=[CH:35][CH:36]=5)[N:33]=[CH:32][CH:31]=[CH:30]6)[CH2:26][CH2:25]4)=[CH:22][N:23]=3)[N:20]=2)=[CH:11][CH:10]=1>>[CH3:18][N:19]([CH3:21])[C:1]([C:3]1[CH:11]=[CH:12][C:15]([C:9]2[CH:10]=[CH:11][C:12]([C:15]3[CH:16]=[N:17][C:18]4[N:19]([C:21]([C:24]5([C:27]6[CH:36]=[C:35]7[C:34](=[CH:29][CH:28]=6)[N:33]=[CH:32][CH:31]=[CH:30]7)[CH2:25][CH2:26]5)=[CH:22][N:23]=4)[N:20]=3)=[CH:13][CH:14]=2)=[CH:16][N:17]=1)=[O:2]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 67223967HCID 67223967, compound

Product 1

HCID 59420909HCID 59420909, compound

Procedure

This compound was prepared as a TFA salt starting from 6-{1-[2-(4-bromophenyl)imidazo[1,2-b][1,2,4]triazin-7-yl]cyclopropyl}quinoline using procedures analogous to those for Example 94. LCMS: (M+H)=512.3

Sources & evidence

ORD record: ord-f3a828b4e7664baa850330acb36a818d
Source dataset: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07767675B2

Reaction notes

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