Ammonia → Methyl 4-(3-amino-1,2,4-triazin-6-yl)benzoate

HRID 500218Notes

Reaction equation

HRID 500218 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:9]=2)=[CH:6][N:7]=1.[NH3:18].C(O)(C)C>O>[NH2:18][C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:9]=2)=[CH:6][N:7]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 3776IsopropanolHCID 59216349Methyl 4-(3-chloro-1,2,4-triazin-6-yl)benzoate

Product 1

HCID 67225162Methyl 4-(3-amino-1,2,4-triazin-6-yl)benzoate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of methyl 4-(3-chloro-1,2,4-triazin-6-yl)benzoate (180 mg, 0.721 mmol) and 2M of ammonia in isopropyl alcohol (5 ml, 10 mmol) was stirred at 25° C. for 3 h. The reaction was diluted with water, and the precipitate was filtered to give the desired product. LCMS: (M+H2O+H)=249.0.

Workup

  1. filtrationthe precipitate was filtered

Sources & evidence

ORD record
ord-533d4c545a0d4a45971ef4a9e1d24895
Source dataset
uspto-grants-2010_08
Patent number
US07767675B2

Reaction notes

Loading…