Trifluoroacetic acid → 4-(7-(1-(Quinolin-6-yl)cyclopropyl)imidazo[1,2-b][1,2,4]triazin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide

HRID 500221Notes

Reaction equation

HRID 500221 reaction equation
[C:1]([OH:7])([C:3](F)(F)F)=O.[N:8]1[C:17]2[C:12](=[CH:13][C:14]([C:18]3([C:21]4[N:25]5[N:26]=[C:27]([C:30]6[CH:38]=[CH:37][C:33]([C:34](O)=[O:35])=[CH:32][CH:31]=6)[CH:28]=[N:29][C:24]5=[N:23][CH:22]=4)[CH2:20][CH2:19]3)=[CH:15][CH:16]=2)[CH:11]=[CH:10][CH:9]=1>>[N:8]1[C:17]2[C:12](=[CH:13][C:14]([C:18]3([C:21]4[N:25]5[N:26]=[C:27]([C:30]6[CH:38]=[CH:37][C:33]([C:34]([NH:8][CH:9]7[CH2:3][CH2:1][O:7][CH2:11][CH2:10]7)=[O:35])=[CH:32][CH:31]=6)[CH:28]=[N:29][C:24]5=[N:23][CH:22]=4)[CH2:20][CH2:19]3)=[CH:15][CH:16]=2)[CH:11]=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 672247994-[7-(1-Quinolin-6-ylcyclopropyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzoic acid

Product 1

HCID 594210054-(7-(1-(Quinolin-6-yl)cyclopropyl)imidazo[1,2-b][1,2,4]triazin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide

Procedure

This compound was prepared as a TFA salt starting from 4-[7-(1-quinolin-6-ylcyclopropyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzoic acid using procedures analogous to those for Example 105. LCMS: (M+H)=491.1.

Sources & evidence

ORD record
ord-a6242bf955fb413f81e0a35d5e9c9ae6
Source dataset
uspto-grants-2010_08
Patent number
US07767675B2

Reaction notes

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