HCID 67224242, compound → HCID 67225308, compound

HRID 500244Notes

Reaction equation

[NH2:1][C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:16]=[CH:15][C:11]([C:12]([OH:14])=[O:13])=[C:10]([F:17])[CH:9]=2)=[CH:4][N:3]=1.Cl[CH:19]([C:22]1([C:25]2[CH:26]=[C:27]3[C:32](=[CH:33][CH:34]=2)[N:31]=[CH:30][CH:29]=[CH:28]3)[CH2:24][CH2:23]1)[CH:20]=O>C(O)C>[F:17][C:10]1[CH:9]=[C:8]([C:5]2[CH:4]=[N:3][C:2]3[N:7]([C:19]([C:22]4([C:25]5[CH:26]=[C:27]6[C:32](=[CH:33][CH:34]=5)[N:31]=[CH:30][CH:29]=[CH:28]6)[CH2:24][CH2:23]4)=[CH:20][N:1]=3)[CH:6]=2)[CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=[O:13]

Participants

Conditions

Temperature: 100 °C

Procedure

A mixture of 4-(2-aminopyrimidin-5-yl)-2-fluorobenzoic acid (0.20 g, 0.86 mmol) and chloro(1-quinolin-6-ylcyclopropyl)acetaldehyde (0.21 g, 0.86 mol) in ethanol (8 mL) was stirred at 100° C. overnight. The reaction mixture was purified by RP-HPLC to afford the desired product. LCMS: (M+H)=425.0.

Workup

customThe reaction mixture was purified by RP-HPLC

Sources & evidence

ORD record: ord-ce6fdb2e529e430a80d0e63c940376ab
Source dataset: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07767675B2

Reaction notes

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