HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 500244Generated: October 30, 2026
HCID 67224242, compound → HCID 67225308, compound
https://huagongshe.com/reaction/500244
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | HCID 67224242 | HCID 67224242 | — |
| Reactant | Chloro(1-quinolin-6-ylcyclopropyl)acetaldehyde | HCID 86621504 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 67225308 | HCID 67225308 | — |
Reaction Steps
A mixture of 4-(2-aminopyrimidin-5-yl)-2-fluorobenzoic acid (0.20 g, 0.86 mmol) and chloro(1-quinolin-6-ylcyclopropyl)acetaldehyde (0.21 g, 0.86 mol) in ethanol (8 mL) was stirred at 100° C. overnight. The reaction mixture was purified by RP-HPLC to afford the desired product. LCMS: (M+H)=425.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07767675B2 |
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| Source dataset | uspto-grants-2010_08 |
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| ORD ID | ord-ce6fdb2e529e430a80d0e63c940376ab |
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| Source note | uspto-grants-2010_08 |
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