Trifluoroacetic acid → Trifluoroacetic acid

HRID 500262Notes

Reaction equation

HRID 500262 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[N:10][C:11]3[N:12]([C:14]([CH2:17][C:18]4[CH:19]=[C:20]([NH:24]C(=O)OC(C)(C)C)[CH:21]=[CH:22][CH:23]=4)=[CH:15][N:16]=3)[N:13]=2)=[CH:4][C:3]=1[F:32].[F:33][C:34]([F:39])([F:38])[C:35]([OH:37])=[O:36]>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[N:10][C:11]3[N:12]([C:14]([CH2:17][C:18]4[CH:19]=[C:20]([CH:21]=[CH:22][CH:23]=4)[NH2:24])=[CH:15][N:16]=3)[N:13]=2)=[CH:4][C:3]=1[F:32].[C:35]([OH:37])([C:34]([F:39])([F:38])[F:33])=[O:36]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86621515HCID 86621515, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 67224335HCID 67224335, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of tert-butyl (3-[2-(4-bromo-3-fluorophenyl)imidazo[1,2-b][1,2,4]triazin-7-yl]methylphenyl)carbamate (10 mg, 0.02 mmol) in trifluoroacetic acid (0.5 mL) and methylene chloride (0.5 mL) was stirred overnight at RT. The mixture was concentrated to afford the desired product as a TFA salt which was directly used for next step. LCMS: (M+H)=397.9/399.9.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-dba6280b15794851a54be998d6dea94e
Source dataset
uspto-grants-2010_08
Patent number
US07767675B2

Reaction notes

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