Hydrochloric Acid → Hydrochloric Acid

HRID 500274Notes

Reaction equation

HRID 500274 reaction equation
[F:1][C:2]1[CH:22]=[C:21]([C:23]2[CH:24]=[N:25][C:26]3[N:27]([C:29]([C:32]4([C:35]5[CH:36]=[C:37]6[C:42](=[CH:43][CH:44]=5)[N:41]=[CH:40][CH:39]=[CH:38]6)[CH2:34][CH2:33]4)=[CH:30][N:31]=3)[CH:28]=2)[CH:20]=[CH:19][C:3]=1[C:4]([NH:6][C@@H:7]([C:15]([CH3:18])([CH3:17])[CH3:16])[C:8]([O:10]C(C)(C)C)=[O:9])=[O:5].[ClH:45]>O1CCOCC1>[F:1][C:2]1[CH:22]=[C:21]([C:23]2[CH:24]=[N:25][C:26]3[N:27]([C:29]([C:32]4([C:35]5[CH:36]=[C:37]6[C:42](=[CH:43][CH:44]=5)[N:41]=[CH:40][CH:39]=[CH:38]6)[CH2:34][CH2:33]4)=[CH:30][N:31]=3)[CH:28]=2)[CH:20]=[CH:19][C:3]=1[C:4]([NH:6][C@@H:7]([C:15]([CH3:18])([CH3:17])[CH3:16])[C:8]([OH:10])=[O:9])=[O:5].[ClH:45]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67224955HCID 67224955, compound

Product 2

HCID 313Hydrochloric AcidHCID 67224992HCID 67224992, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of tert-butyl (2S)-2-(2-fluoro-4-[3-(1-quinolin-6-ylcyclopropyl)imidazo[1,2-a]pyrimidin-6-yl]benzoylamino)-3,3-dimethylbutanoate (60 mg, 0.1 mmol) in 2.0 ml of 4N HCl in 1,4-dioxane was stirred for 1 h. The mixture was concentrated to give the desired product as an HCl salt. LCMS: (M+H)=538.1.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-f7132684aaf34d309176aa67b9374c45
Source dataset
uspto-grants-2010_08
Patent number
US07767675B2

Reaction notes

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