反应详情

Sodium borohydride (0.03 g, 0.0008 mol) was added to a mixture of 5-acetyl-3-(3,5-dimethylphenylsulfonyl)indole-2-carboxyamide (51) (0.30 g, 0.0008 mol) in tetrahydrofuran (8.5 mL) containing 0.1 mL of water, then reaction was refluxed for 1 hour. After cooling, water was added while stirring for a few minutes, then the mixture was extracted with ethyl acetate, washed with brine and dried. Removal of the solvent furnished 0.25 g (83%) of satisfactory pure title compound, mp 260-260° C. (ethanol).

1. customreaction
2. temperaturewas refluxed for 1 hour
3. temperatureAfter cooling
4. extractionthe mixture was extracted with ethyl acetate
5. washwashed with brine
6. customdried
7. customRemoval of the solvent