HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-Hydroxyethyl)piperazine → 1-Acetyl-4-(2-hydroxyethyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-Hydroxyethyl)piperazine | HCID 7677 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Acetyl-4-(2-hydroxyethyl)piperazine | HCID 4739629 | 65% |
Reaction Steps
A solution of 2-(1-piperazinyl)-1-ethanol (6.5 g 0.05 mol) in DCM (5 mL) was treated with acetic acid anhydride (5.1 g, 0.05 mol), added dropwise. During addition, the reaction temperature rose from 22 to 60° C. The reaction mixture was evaporated several times with toluene to yield 5.6 g (65%) of the sub-title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07772229B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-d4d753808d88424382dcf7134625b815 |
| Source note | uspto-grants-2010_08 |