反应详情

温度

135 °C

To solid 6-chloro-3-(2-fluoro-4-iodo-phenylamino)-pyridazine-4-carboxylic acid (34 mg, 0.09 mmol) in DMF was added NaOMe (0.43 mmol, 0.5 M in MeOH). The mixture was heated at 135° C. for 3 h. The mixture was diluted with ether and extracted with NaOH (1N). The aqueous layer was acidified by concentrated HCl. The desired product was precipitated and was collected by vacuum filtration. LC/MS [8.08 min; 390 (M+1)].

1. extractionextracted with NaOH (1N)
2. customThe desired product was precipitated
3. filtrationwas collected by vacuum filtration
4. customLC/MS [8.08 min; 390 (M+1)]