反应详情

温度

60 °C

8.6 g of triethylamine and 20 ml of water are added to a solution of 10 g of isonipecotic acid in 100 ml of dioxane and the mixture is heated to 60° C. 20.25 g of di-tert-butyl carbonate are then added dropwise and the mixture is stirred for 1 hour at 60° C. and refluxed for 30 minutes. It is concentrated under vacuum, the residue is taken up with water and acidified to pH 3 by the addition of 2 N HCl solution and the precipitate formed is filtered off to give 17 g of the expected product.

1. temperaturerefluxed for 30 minutes
2. concentrationIt is concentrated under vacuum
3. additionacidified to pH 3 by the addition of 2 N HCl solution
4. customthe precipitate formed
5. filtrationis filtered off