反应详情

温度

80 °C

The title compound of example 26.1 (6.4 g, 23.9 mmol) was dissolved in acetic acid (190 mL) and 20-30% hydrogen bromide in ethanol (190 mL) was added to the reaction. It was allowed to stir at 80° C. for 3.5 hours. The reaction was concentrated once, diluted with ethanol and concentrated again. Ethanol was added once more and the mixture was sonicated until a precipitate formed. The solid was filtered and dried under vacuum to afford the title compound (6.77 g, 85%) as a white solid.

1. concentrationThe reaction was concentrated once
2. additiondiluted with ethanol
3. concentrationconcentrated again
4. additionEthanol was added once more
5. customthe mixture was sonicated until a precipitate
6. customformed
7. filtrationThe solid was filtered
8. customdried under vacuum