HRID50068

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11430

Potassium Carbonate

CK2O3

HCID417393

未命名化合物

结构：CC(=O)N(C)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCCCN(C(=O)c3ccccc3)C2)CC1.Cl

HCID22741746

未命名化合物

PRODUCTS

生成物

结构：CN(C)C(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCCCN(C(=O)c3ccccc3)C2)CC1.CN(C)C(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCCCN(C(=O)c3ccccc3)C2)CC1.Cl.Cl.O

HCID131721656

未命名化合物

收率 80.2%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21891449

未命名化合物

PROCEDURE

实验过程

This compound is prepared by the procedure described in step D of EXAMPLE 13, starting from 0.69 g of 4-(N,N-dimethylaminocarbonyl)-4-phenyl-piperidine, 1.2 g of the compound obtained in step C of EXAMPLE 13 and 1.2 g of K2CO3 in 20 ml of a DMF/acetonitrile mixture (50/50; v/v). This gives 0.65 g of the expected product, m.p.=150° C.

WORKUP

后处理

customThis compound is prepared by the procedure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0142b026401141c2b99136f61598949b
来源数据集: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06710042B2
来源说明: uspto-grants-2004_03

反应 SMILES

[CH3:1][N:2]([CH3:17])[C:3]([C:5]1([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1)=[O:4].[ClH:18].C(N([C:24]1([C:56]2[CH:61]=[CH:60][CH:59]=[CH:58][CH:57]=2)[CH2:29][CH2:28][N:27]([CH2:30][CH2:31][CH2:32][C:33]2([C:48]3[CH:53]=[CH:52][C:51]([Cl:54])=[C:50]([Cl:55])[CH:49]=3)[CH2:39][CH2:38][CH2:37][CH2:36][N:35]([C:40](=[O:47])[C:41]3[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=3)[CH2:34]2)[CH2:26][CH2:25]1)C)(=O)C.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C.C(#N)C>[OH2:4].[ClH:54].[C:40]([N:35]1[CH2:36][CH2:37][CH2:38][CH2:39][C:33]([C:48]2[CH:53]=[CH:52][C:51]([Cl:54])=[C:50]([Cl:55])[CH:49]=2)([CH2:32][CH2:31][CH2:30][N:8]2[CH2:7][CH2:6][C:5]([C:3]([N:2]([CH3:17])[CH3:1])=[O:4])([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH2:10][CH2:9]2)[CH2:34]1)(=[O:47])[C:41]1[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=1.[C:40]([N:35]1[CH2:36][CH2:37][CH2:38][CH2:39][C:33]([CH2:32][CH2:31][CH2:30][N:27]2[CH2:28][CH2:29][C:24]([C:56]3[CH:61]=[CH:60][CH:59]=[CH:58][CH:57]=3)([C:3]([N:2]([CH3:17])[CH3:1])=[O:4])[CH2:25][CH2:26]2)([C:48]2[CH:53]=[CH:52][C:51]([Cl:54])=[C:50]([Cl:55])[CH:49]=2)[CH2:34]1)(=[O:47])[C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1.[ClH:18]