Piperidine → 4-Piperidin-1-yl-but-2-enoic acid methyl ester

HRID 500695Notes

Reaction equation

HRID 500695 reaction equation
Br[CH2:2]/[CH:3]=[CH:4]/[C:5]([O:7][CH3:8])=[O:6].[NH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1>ClCCl>[CH3:8][O:7][C:5](=[O:6])[CH:4]=[CH:3][CH2:2][N:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 53691752-Butenoic acid, 4-bromo-, methyl ester

Product 1

HCID 572293064-Piperidin-1-yl-but-2-enoic acid methyl ester

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

Methyl 4-bromocrotonate (2 g, 11.2 mmol) was dissolved in dichloromethane (20 mL) and cooled to 0° C. Piperidine (1.11 mL, 11.2 mmol) was added slowly. The mixture was stirred at 0° C. for 1 hour. The solvent was removed in vacuo. The crude material was used as is. MS m/z 184 (M+1).

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-48569a9bcca8490f8543bbcab0e8e3cd
Source dataset
uspto-grants-2010_08
Patent number
US07772243B2

Reaction notes

Loading…