Dodecylamine → HCID 59424435, compound

HRID 500815Notes

Reaction equation

HRID 500815 reaction equation
S1C=CN=C1C1SC2C(=NC=CC=2OC2C=CC(NC(NC(=O)CC3C=CC=CC=3)=S)=CC=2F)C=1.CCCCCCCCCCCCN.[F:49][C:50]1[CH:51]=[C:52]([NH:71]C(NC(=O)CC2C=CC=CC=2)=S)[CH:53]=[CH:54][C:55]=1[O:56][C:57]1[C:58]2[S:65][C:64]([C:66]3[S:67][CH:68]=[CH:69][N:70]=3)=[CH:63][C:59]=2[N:60]=[CH:61][N:62]=1>>[F:49][C:50]1[CH:51]=[C:52]([NH2:71])[CH:53]=[CH:54][C:55]=1[O:56][C:57]1[C:58]2[S:65][C:64]([C:66]3[S:67][CH:68]=[CH:69][N:70]=3)=[CH:63][C:59]=2[N:60]=[CH:61][N:62]=1

Participants

4

Reactant 3

HCID 13583DodecylamineHCID 11598848HCID 11598848, compoundHCID 86604174HCID 86604174, compound

Product 1

HCID 59424435HCID 59424435, compoundYield 7%

Procedure

Starting from the nitro compound 150, following the procedure described above for the synthesis of compound 13a (via the intermediate amine 12, scheme 2, example 12), title compound 152a was obtained [via intermediate 3-fluoro-4-(6-(thiazol-2-yl)thieno[3,2-d]pyrimidin-4-yloxy)benzenamine (151)] in 7% yield. Characterization of 152a is provided in the Table 14.

Sources & evidence

ORD record
ord-e759033f08a24991a7c7a553443d6e4e
Source dataset
uspto-grants-2010_08
Patent number
US07772247B2

Reaction notes

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