HRID500839

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID21890610

未命名化合物

结构：O=C(Cc1ccccc1)NC(=S)Nc1ccc(Oc2ccnc3ccsc23)c(F)c1

HCID24901699

未命名化合物

结构：O=C(Cc1ccccc1)NC(=S)Nc1ccc(Oc2ncnc3c2ccn3Cc2ccccc2)c(F)c1

HCID86609660

未命名化合物

PRODUCTS

生成物

结构：O=C(NC(=S)Nc1ccc(Oc2ccnc3ccsc23)c(F)c1)C1(c2ccccc2)CC1

HCID86604183

未命名化合物

收率 41%

PROCEDURE

实验过程

Starting from the amine 169 (scheme 33), following the procedures described above for the synthesis of compound 170a (example 133) but replacing 2-phenylacetyl isothiocyanate with 1-phenylcyclopropanecarbonyl isothiocyanate, title compound 192d was obtained in 41% yield. Characterization of 192d is provided in table 18.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d43cd4bddb554b2abe707f2257522a32
来源数据集: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07772247B2
来源说明: uspto-grants-2010_08

反应 SMILES

[CH2:1](N1C2N=CN=C(OC3C=CC(NC(NC(=O)CC4C=CC=CC=4)=S)=CC=3F)C=2C=C1)[C:2]1C=CC=CC=1.[F:38][C:39]1[CH:40]=[C:41]([NH:55][C:56]([NH:58][C:59](=[O:67])[CH2:60][C:61]2[CH:66]=[CH:65][CH:64]=[CH:63][CH:62]=2)=[S:57])[CH:42]=[CH:43][C:44]=1[O:45][C:46]1[CH:51]=[CH:50][N:49]=[C:48]2[CH:52]=[CH:53][S:54][C:47]=12.C1(C2(C(N=C=S)=O)CC2)C=CC=CC=1>>[F:38][C:39]1[CH:40]=[C:41]([NH:55][C:56]([NH:58][C:59]([C:60]2([C:61]3[CH:62]=[CH:63][CH:64]=[CH:65][CH:66]=3)[CH2:2][CH2:1]2)=[O:67])=[S:57])[CH:42]=[CH:43][C:44]=1[O:45][C:46]1[CH:51]=[CH:50][N:49]=[C:48]2[CH:52]=[CH:53][S:54][C:47]=12