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1-Phenylcyclopropanecarbonyl isothiocyanate → N-(3-Fluoro-4-(thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl) 1-phenylcyclopropanecarboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Phenylcyclopropanecarbonyl isothiocyanate | HCID 21890610 | — |
| 反応物 | N-(3-Fluoro-4-(thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide | HCID 24901699 | — |
| 反応物 | 1-(4-(7-Benzyl-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)-3-fluorophenyl)-3-(2-phenylacetyl)thiourea | HCID 86609660 | — |
| 生成物 | N-(3-Fluoro-4-(thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl) 1-phenylcyclopropanecarboxamide | HCID 86604183 | 41% |
反応手順
Starting from the amine 169 (scheme 33), following the procedures described above for the synthesis of compound 170a (example 133) but replacing 2-phenylacetyl isothiocyanate with 1-phenylcyclopropanecarbonyl isothiocyanate, title compound 192d was obtained in 41% yield. Characterization of 192d is provided in table 18.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07772247B2 |
| 出典データセット | uspto-grants-2010_08 |
| ORD ID | ord-d43cd4bddb554b2abe707f2257522a32 |
| 出典メモ | uspto-grants-2010_08 |