N-(4-(2-(1-Methyl-1H-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide → 4-(2-(Methylsulfinyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorobenzenamine

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	N-(4-(2-(1-Methyl-1H-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenylcarbamothioyl)-2-phenylacetamide	HCID 11962454	—
Edukt	7-chloro-2-(1-methyl-1H-imidazol-2-yl)-thieno[3,2-b]pyridine	HCID 22143563	—
Edukt	N-(3-Fluoro-4-(2-(1-methyl-1H-imidazol-2-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl carbamothioyl)-2-(2-fluorophenyl)acetamide di-hydrochloride	HCID 86604196	—
Produkt	4-(2-(Methylsulfinyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorobenzenamine	HCID 59424528	31%

Reaktionsschritte

Starting from the compound 214 (scheme 46) and following the procedures described above for the synthesis of compound 228 (example 202) and 303a (example 232), title compound 234 was obtained in 31% yield as an off-white solid. H NMR (d-DMSO) δ (ppm): 12.34(s, 1H), 11.81(s, 1H), 8.68(m, 1H,), 8.24(s, 1H), 7.79(m, 3H), 7.62(s, 1H), 7.40-7.13(m, 6H), 6.86(d, 1H), 4.02(s, 3H), 3.93(s, 2H). MS (m/z): 518.1(M+H) (found).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07772247B2
Quelldatensatz	uspto-grants-2010_08
ORD ID	ord-f4e69b67442443e7a69322cd696b65a8
Quellennotiz	uspto-grants-2010_08