反应详情

10% Pd—C (hydrous product; 7.89 g) and ammonium formate (11.96 g) were added to a solution of 6-chloro-4-(4-methoxy-2-methylphenyl)-3-pyridazineamine (7.89 g) in methanol (100 mL), and the mixture was heated under reflux for 1.5 hours. The reaction mixture was filtered through Celite, and the solvent was evaporated. The resulting residue was purified by silica gel column chromatography (ethyl acetate:ethanol=10:1) to give the title compound (6.16 g) as white crystals.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 1.5 hours
3. filtrationThe reaction mixture was filtered through Celite
4. customthe solvent was evaporated
5. customThe resulting residue was purified by silica gel column chromatography (ethyl acetate:ethanol=10:1)