Sodium Hydroxide → HCID 22024327, compound

HRID 501026Notes

Reaction equation

HRID 501026 reaction equation
Cl.C(OCC)(=O)C.[CH3:8][C:9]1[CH:14]=[C:13]([CH3:15])[CH:12]=[CH:11][C:10]=1[C:16]1[C:17]2[N:18]([C:23]([NH:28]C(=O)OC(C)(C)C)=[C:24]([CH2:26][CH3:27])[N:25]=2)[N:19]=[C:20]([CH3:22])[CH:21]=1.[OH-].[Na+]>C(OCC)(=O)C>[CH3:8][C:9]1[CH:14]=[C:13]([CH3:15])[CH:12]=[CH:11][C:10]=1[C:16]1[C:17]2[N:18]([C:23]([NH2:28])=[C:24]([CH2:26][CH3:27])[N:25]=2)[N:19]=[C:20]([CH3:22])[CH:21]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 21866389Hydrogen chloride-ethyl acetateHCID 22024686HCID 22024686, compound

Product 1

HCID 22024327HCID 22024327, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4N hydrochloric acid/ethyl acetate (30 mL) was added to a solution of the resulting tert-butyl N-[8-(2,4-dimethylphenyl)-2-ethyl-6-methylimidazo[1,2-b]pyridazin-3-yl]carbamate in ethyl acetate (10 mL), and the mixture was stirred at room temperature for 14 hours. The mixture was neutralized by adding 5N aqueous sodium hydroxide solution under ice-cooling, which was extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous magnesium sulfate and evaporated, to give 8-(2,4-dimethylphenyl)-2-ethyl-6-methylimidazo[1,2-b]pyridazin-3-amine as a crude product.

Workup

  1. temperaturecooling
  2. extractionwhich was extracted with ethyl acetate
  3. washThe organic layer was washed with brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customevaporated

Sources & evidence

ORD record
ord-94eabc5d9044438993f8b79a03d72cca
Source dataset
uspto-grants-2010_08
Patent number
US07772249B2

Reaction notes

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