Sodium Hydroxide → HCID 22024329, compound

HRID 501030Notes

Reaction equation

HRID 501030 reaction equation
Cl.C(OCC)(=O)C.[CH3:8][C:9]1[CH:14]=[C:13]([CH3:15])[CH:12]=[CH:11][C:10]=1[C:16]1[C:17]2[N:18]([C:22]([NH:27]C(=O)OC(C)(C)C)=[C:23]([CH2:25][CH3:26])[N:24]=2)[N:19]=[CH:20][CH:21]=1.[OH-].[Na+]>C(OCC)(=O)C>[CH3:8][C:9]1[CH:14]=[C:13]([CH3:15])[CH:12]=[CH:11][C:10]=1[C:16]1[C:17]2[N:18]([C:22]([NH2:27])=[C:23]([CH2:25][CH3:26])[N:24]=2)[N:19]=[CH:20][CH:21]=1

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 21866389Hydrogen chloride-ethyl acetateHCID 22024400HCID 22024400, compound

Product 1

HCID 22024329HCID 22024329, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

4N hydrochloric acid/ethyl acetate (15 mL) was added to a solution of the crude tert-butyl N-[8-(2,4-dimethylphenyl)-2-ethylimidazo[1,2-b]pyridazin-3-yl]carbamate in ethyl acetate (5 mL), and the mixture was stirred at room temperature for 15 hours. The mixture was neutralized by adding a 5N aqueous sodium hydroxide solution under ice-cooling, and extracted with ethyl acetate. It was washed with brine, dried over anhydrous magnesium sulfate and evaporated, to give crude 8-(2,4-dimethylphenyl)-2-ethylimidazo[1,2-b]pyridazin-3-amine.

Workup

  1. temperaturecooling
  2. extractionextracted with ethyl acetate
  3. washIt was washed with brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customevaporated

Sources & evidence

ORD record
ord-2462488fe4954df0ac743a406efd5919
Source dataset
uspto-grants-2010_08
Patent number
US07772249B2

Reaction notes

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