Hydrazine hydrate (1:1) → 3-[(1-Benzylpiperidin-4-yl)amino]pyrazine-2-carbohydrazide

HRID 501075Notes

Reaction equation

HRID 501075 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[C:16]([C:21](OC)=[O:22])=[N:17][CH:18]=[CH:19][N:20]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.[NH2:26][NH2:27]>C(O)C>[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[C:16]([C:21]([NH:26][NH2:27])=[O:22])=[N:17][CH:18]=[CH:19][N:20]=2)[CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 22293191Methyl 3-[(1-benzylpiperidin-4-yl)amino]pyrazine-2-carboxylate

Product 1

HCID 222933153-[(1-Benzylpiperidin-4-yl)amino]pyrazine-2-carbohydrazide

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of methyl 3-[(1-benzylpiperidin-4-yl)amino]pyrazine-2-carboxylate (3.0 g, 9.2 mmol) and hydrazine hydrate (6 mL) in ethanol (100 mL) was refluxed with stirring for 2 h. The reaction was cooled and concentrated to give the title compound (3.0 g). MS 327 (M+1).

Workup

  1. temperaturewas refluxed
  2. temperatureThe reaction was cooled
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-5a88e9f45cc242be932d0f0e08d5e56a
Source dataset
uspto-grants-2010_08
Patent number
US07772224B2

Reaction notes

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