反应详情

10% Platinum on carbon (320 mg) was added to a solution of 5-(2,3-difluorophenyl)-1-(2-methoxyethyl)-3-nitropyridin-2(1H)-one (300 mg, 0.967 mmol) in acetic acid (10 mL). The reaction vessel was evacuated and back-filled with nitrogen (3×), then back-filled with hydrogen (56 psi). After 65 h, the mixture was filtered and concentrated. MS 285 (M+1).

1. customThe reaction vessel was evacuated
2. additionback-filled with nitrogen (3×)
3. additionback-filled with hydrogen (56 psi)
4. filtrationthe mixture was filtered
5. concentrationconcentrated