反应详情

A solution of indoline (10 g, 840 mmol) in dichloromethane (400 mL) was treated with 88% formic acid (48.8 g, 924 mmol), heated to reflux, and stirred for 2.5 hours. The mixture was concentrated to 2/3 of the original volume, diluted with 1,2-dichloroethane (200 mL), and again concentrated to 2/3 of the original volume to provide a solution of N-formylindoline in 1,2-dichloroethane, which was used without further purification.

1. temperatureheated
2. temperatureto reflux
3. concentrationThe mixture was concentrated to 2/3 of the original volume
4. additiondiluted with 1,2-dichloroethane (200 mL)
5. concentrationagain concentrated to 2/3 of the original volume