Chlorosulfonic acid → 2-Acetamido-2,3-dihydro-1h-indene-5-sulfonyl chloride

Participants

Reaction Steps

1.6 ml of chloro sulfonic acid was dropped to the stirred solution of 1.06 g N-Indan-2-yl-acetamide and 50 ml of dichloromethane and the mixture was stirred for 15 hours at room temperature. The reaction was than quenched with cold water and die organic phase separated, dried over sodium sulfate evaporated. The resulting residue was used for further reaction without further purification.

Provenance & Evidence