Hydrochloric Acid → HCID 178427990, compound

HRID 501248Notes

Reaction equation

HRID 501248 reaction equation
[O:1]=[S:2]1(=[O:30])[CH2:6][CH:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[CH2:4][N:3]1[C:13]1[C:24]([S:25]([CH3:28])(=[O:27])=[O:26])=[CH:23][C:16]([C:17]([NH:19][C:20]([NH2:22])=[NH:21])=[O:18])=[C:15]([CH3:29])[CH:14]=1.[ClH:31]>CC(C)=O>[ClH:31].[O:30]=[S:2]1(=[O:1])[CH2:6][CH:5]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:4][N:3]1[C:13]1[C:24]([S:25]([CH3:28])(=[O:26])=[O:27])=[CH:23][C:16]([C:17]([NH:19][C:20]([NH2:22])=[NH:21])=[O:18])=[C:15]([CH3:29])[CH:14]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178427989HCID 178427989, compound

Product 1

HCID 178427990HCID 178427990, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

737 mg of N-[4-(1,1-dioxo-4-phenylisothiazolidin-2-yl)-5-methanesulfonyl-2-methylbenzoyl]guanidine were dissolved in 20 ml of acetone, and 2 ml of a 2N aqueous HCl solution were added. The volatile constituents were then removed in vacuo. This was followed by coevaporation 3 times with 20 ml of toluene each time and finally drying under medium vacuum. 728 mg of white crystals were obtained, mp 259° C. (with decomposition).

Workup

  1. customThe volatile constituents were then removed in vacuo
  2. customfinally drying under medium vacuum

Sources & evidence

ORD record
ord-f4832f2328b642338a6bea03f548a4b3
Source dataset
uspto-grants-2010_08
Patent number
US07772262B2

Reaction notes

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