Hydrochloric Acid → HCID 178427992, compound

HRID 501253Notes

Reaction equation

HRID 501253 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:12][S:11](=[O:14])(=[O:13])[N:10]([C:15]3[C:26]([S:27]([CH3:30])(=[O:29])=[O:28])=[CH:25][C:18]([C:19]([NH:21][C:22]([NH2:24])=[NH:23])=[O:20])=[C:17]([CH3:31])[CH:16]=3)[CH2:9]2)=[CH:4][CH:3]=1.[ClH:32]>CC(C)=O>[ClH:32].[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:12][S:11](=[O:13])(=[O:14])[N:10]([C:15]3[C:26]([S:27]([CH3:30])(=[O:29])=[O:28])=[CH:25][C:18]([C:19]([NH:21][C:22]([NH2:24])=[NH:23])=[O:20])=[C:17]([CH3:31])[CH:16]=3)[CH2:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178427991HCID 178427991, compound

Product 1

HCID 178427992HCID 178427992, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

562 mg of N-{4-[4-(4-fluorophenyl)-1,1-dioxoisothiazolidin-2-yl]-5-methanesulfonyl-2-methylbenzoyl}guanidine were dissolved in 20 ml of acetone and 2 ml of a 4N aqueous HCl solution added. The volatile constituents were removed in vacuo, followed by coevaporation 3 times with 20 ml of toluene each time and finally drying under medium vacuum. 587 mg of white crystals were obtained, mp 250° C. (with decomposition).

Workup

  1. customThe volatile constituents were removed in vacuo
  2. customfinally drying under medium vacuum

Sources & evidence

ORD record
ord-b4d19bd432934dc5a64afe3d04763ee1
Source dataset
uspto-grants-2010_08
Patent number
US07772262B2

Reaction notes

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