Hydrochloric Acid → HCID 23112489, compound

HRID 501318Notes

Reaction equation

HRID 501318 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14]2[C:18]3[CH:19]=[CH:20][CH:21]=[C:22]([O:23][CH3:24])[C:17]=3[O:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:25].CO>CCOCC>[ClH:25].[CH3:24][O:23][C:22]1[C:17]2[O:16][N:15]=[C:14]([CH:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)[C:18]=2[CH:19]=[CH:20][CH:21]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 58817635HCID 58817635, compound

Product 1

HCID 23112489HCID 23112489, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

A mixture of 4-(7-Methoxy-benzo[d]isoxazol-3-yl)-piperidine-1-carboxylic acid tert-butyl ester (3.00 g, 9.03 mmol), HCl (35 mL of a 1 M ether solution, 35.0 mmol), and methanol (25 mL) was stirred at room temperature under nitrogen for 18 h. Ether (75 mL) was added, the mixture stirred at room temperature for 15 min, and the product collected by filtration to afford 2.37 g (98%) of the desired product as a white powder, mp: >250° C.

Workup

  1. stirringthe mixture stirred at room temperature for 15 min
  2. filtrationthe product collected by filtration

Sources & evidence

ORD record
ord-f8a5ae810cc94da9946acfc21e070653
Source dataset
uspto-grants-2010_08
Patent number
US07772252B2

Reaction notes

Loading…