Hydrogen Bromide → HCID 23112415, compound

HRID 501337Notes

Reaction equation

HRID 501337 reaction equation
COC([N:5]1[CH2:10][CH2:9][CH:8]([C:11]2[C:12]3[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][C:13]=3[S:14][CH:15]=2)[CH2:7][CH2:6]1)=O.[BrH:24]>>[BrH:24].[F:23][C:20]([F:21])([F:22])[C:17]1[CH:18]=[CH:19][C:12]2[C:11]([CH:8]3[CH2:7][CH2:6][NH:5][CH2:10][CH2:9]3)=[CH:15][S:14][C:13]=2[CH:16]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 58817563HCID 58817563, compound

Product 1

HCID 23112415HCID 23112415, compoundYield 94%

Procedure

A mixture of 4-(6-trifluoromethyl-benzo[b]thiophen-3-yl)-piperidine-1-carboxylic acid methyl ester (3.1 g, 9.0 mmol) in HBr (45 mL, 30% in acetic acid) was stirred at room temperature for 20 hours when the volatiles were removed in vacuo. The residue was washed with EtOAc and the product was collected by filtration yielding 3.09 g (94%) of the desired product as a white solid.

Workup

  1. customwere removed in vacuo
  2. washThe residue was washed with EtOAc
  3. filtrationthe product was collected by filtration

Sources & evidence

ORD record
ord-0413b12ce85545ef9b5212370cdc3d78
Source dataset
uspto-grants-2010_08
Patent number
US07772252B2

Reaction notes

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