Hydrochloric Acid → HCID 23536936, compound

Participants

Reaction Steps

2.227 g of t-butyl 4-[7-(2-chlorophenyl)-1,3-bis-(2,2-dimethylpropionyloxymethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]piperazine-1-carboxylate was dissolved in a mixture of 10 ml of tetrahydrofuran and 20 ml of methanol, and 0.518 ml of 1,8-diazabicyclo[5,4,0]undec-7-ene was added thereto. The mixture was stirred at room temperature overnight. 1N hydrochloric acid was added to the mixture, and the precipitated solid was collected by filtration. The solid was dried to give 1.025 g of the title compound.

Provenance & Evidence