Hydrochloric Acid → HCID 23536936, compound

HRID 501373Notes

Reaction equation

HRID 501373 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:16]2[C:15](=[O:17])[N:14]([CH2:18][O:19][C:20](=[O:25])[C:21]([CH3:24])([CH3:23])[CH3:22])[C:13](=[O:26])[N:12](COC(=O)C(C)(C)C)[C:11]=2[N:10]=[C:9]1[N:35]1[CH2:40][CH2:39][N:38]([C:41]([O:43][C:44]([CH3:47])([CH3:46])[CH3:45])=[O:42])[CH2:37][CH2:36]1.Cl>O1CCCC1.CO.N12CCCN=C1CCCCC2>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:16]2[C:15](=[O:17])[N:14]([CH2:18][O:19][C:20](=[O:25])[C:21]([CH3:24])([CH3:23])[CH3:22])[C:13](=[O:26])[NH:12][C:11]=2[N:10]=[C:9]1[N:35]1[CH2:40][CH2:39][N:38]([C:41]([O:43][C:44]([CH3:47])([CH3:46])[CH3:45])=[O:42])[CH2:37][CH2:36]1

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 23070645HCID 23070645, compound

Product 1

HCID 23536936HCID 23536936, compoundYield 55.4%

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolventHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneSolvent

Procedure

2.227 g of t-butyl 4-[7-(2-chlorophenyl)-1,3-bis-(2,2-dimethylpropionyloxymethyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]piperazine-1-carboxylate was dissolved in a mixture of 10 ml of tetrahydrofuran and 20 ml of methanol, and 0.518 ml of 1,8-diazabicyclo[5,4,0]undec-7-ene was added thereto. The mixture was stirred at room temperature overnight. 1N hydrochloric acid was added to the mixture, and the precipitated solid was collected by filtration. The solid was dried to give 1.025 g of the title compound.

Workup

  1. additionwas added
  2. filtrationthe precipitated solid was collected by filtration
  3. customThe solid was dried

Sources & evidence

ORD record
ord-c786b3c8114d4be8a3a3505b7119be12
Source dataset
uspto-grants-2010_08
Patent number
US07772226B2

Reaction notes

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