HCID 23070956, compound → HCID 23071025, compound

HRID 501381Notes

Reaction equation

HRID 501381 reaction equation
[CH2:1]([N:5]1[C:13]2[C:12](=[O:14])[N:11]([CH3:15])[C:10]([C:16](=[O:18])[NH2:17])=[N:9][C:8]=2[N:7]=[C:6]1[N:19]1[CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21][CH2:20]1)[C:2]#[C:3][CH3:4]>FC(F)(F)C(O)=O>[CH2:1]([N:5]1[C:13]2[C:12](=[O:14])[N:11]([CH3:15])[C:10]([C:16]([NH2:17])=[O:18])=[N:9][C:8]=2[N:7]=[C:6]1[N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1)[C:2]#[C:3][CH3:4]

Participants

3

Reactant 1

HCID 23070956HCID 23070956, compound

Product 1

HCID 23071025HCID 23071025, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

77 mg of t-butyl 4-[7-(2-butynyl)-2-carbamoyl-1-methyl-6-oxo-6,7-dihydro-1H-purin-8-yl]piperazine-1-carboxylate was dissolved in 1 ml of trifluoroacetic acid, and the solution was concentrated. The residue was purified by chromatography using NH-silica gel. Thus, 49 mg of the title compound was obtained from the fraction eluted with ethyl acetate-methanol (5:1)

Workup

  1. concentrationthe solution was concentrated
  2. customThe residue was purified by chromatography

Sources & evidence

ORD record
ord-c174a36280a34c2087013a82ae59aeca
Source dataset
uspto-grants-2010_08
Patent number
US07772226B2

Reaction notes

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