Trifluoroacetic acid → HCID 135829591, compound

HRID 501385Notes

Reaction equation

HRID 501385 reaction equation
[CH2:1]([N:5]1[C:13]2[C:12](=[O:14])[NH:11][C:10]([Cl:15])=[N:9][C:8]=2[N:7]=[C:6]1[N:16]1[CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18][CH2:17]1)[C:2]#[C:3][CH3:4].[F:29][C:30]([F:35])([F:34])[C:31]([OH:33])=[O:32]>>[F:29][C:30]([F:35])([F:34])[C:31]([OH:33])=[O:32].[CH2:1]([N:5]1[C:13]2[C:12](=[O:14])[NH:11][C:10]([Cl:15])=[N:9][C:8]=2[N:7]=[C:6]1[N:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1)[C:2]#[C:3][CH3:4]

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 135829587HCID 135829587, compound

Product 1

HCID 135829591HCID 135829591, compound

Procedure

8 mg of t-butyl 4-[7-(2-butynyl)-2-chloro-6-oxo-6,7-dihydro-1H-purin-8-yl]piperazine-1-carboxylate was dissolved in trifluoroacetic acid, and the solution was concentrated. The residue was purified by reverse-phase high performance liquid chromatography (using an acetonitrile-water mobile phase (containing 0.1% trifluoroacetic acid)) to give 3.45 mg of the title compound.

Workup

  1. concentrationthe solution was concentrated
  2. customThe residue was purified by reverse-phase high performance liquid chromatography (

Sources & evidence

ORD record
ord-42a15f2b2c424de184c7b719ba042ec8
Source dataset
uspto-grants-2010_08
Patent number
US07772226B2

Reaction notes

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