Trifluoroacetic acid → HCID 16730427, compound

HRID 501397Notes

Reaction equation

HRID 501397 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH2:8]([N:12]1[C:16]2[C:17](=[O:22])[N:18]([CH3:21])[N:19]=[CH:20][C:15]=2[N:14]=[C:13]1[N:23]1[CH2:28][CH2:27][N:26](C(OC(C)(C)C)=O)[CH2:25][CH2:24]1)[C:9]#[C:10][CH3:11]>ClCCl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH2:8]([N:12]1[C:16]2[C:17](=[O:22])[N:18]([CH3:21])[N:19]=[CH:20][C:15]=2[N:14]=[C:13]1[N:23]1[CH2:24][CH2:25][NH:26][CH2:27][CH2:28]1)[C:9]#[C:10][CH3:11]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57472499HCID 57472499, compound

Product 1

HCID 16730427HCID 16730427, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.4 ml of trifluoroacetic acid was added to a 0.4-ml dichloromethane solution of 0.0351 g of t-butyl 4-[1-(2-butynyl)-6-methyl-7-oxo-6,7-dihydro-1H-imidazo[4,5-d]pyridazin-2-yl]piperazine-1-carboxylate, and the mixture was stirred at room temperature for one hour. The solvent was concentrated. The residue was purified by reverse-phase high performance liquid chromatography (using an acetonitrile-water mobile phase (containing 0.1% trifluoroacetic acid)) to give 0.0295 g of the title compound.

Workup

  1. concentrationThe solvent was concentrated
  2. customThe residue was purified by reverse-phase high performance liquid chromatography (

Sources & evidence

ORD record
ord-f398e8254e1b47bca896e7c7c024fdda
Source dataset
uspto-grants-2010_08
Patent number
US07772226B2

Reaction notes

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