HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Hydrazinyl-6-methoxy-1,3-benzothiazole → 5-(4-Chlorophenyl)-3-(3-hydroxypropyl)-1-(6-methoxy-2-benzothiazolyl)pyrazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Hydrazinyl-6-methoxy-1,3-benzothiazole | HCID 1987846 | — |
| Reactant | 1-(4-Chlorophenyl)-6-hydroxyhexan-1,3-dione | HCID 14497414 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 5-(4-Chlorophenyl)-3-(3-hydroxypropyl)-1-(6-methoxy-2-benzothiazolyl)pyrazole | HCID 19797564 | 80.9% |
Reaction Steps
6-(4-Chlorophenyl)-4,6-diketohexanol (14.43 g, 60 mM) was treated with 2-hydrazino-6-methoxybenzothiazole (11.72 g, 60 mM) in pyridine (10 ml) and MeOH (300 ml) at reflux for 72 hr. Work-up as described in Example 1 followed by recrystallization from MeOH afforded the title compound 6 as a white solid (19.4 g), mp=123°-125° C.; NMR(CDCl3) δ 6.3 (s, 1H, C4 -H); MS, m/e 399 (M+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05242940 |
| Source dataset | uspto-grants-1993_09 |
| ORD ID | ord-c264e2331d7b4273ae53b165f3a42301 |
| Source note | uspto-grants-1993_09 |