HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 501426Generated: October 29, 2026
Salicylamide → 2-[7-(2-Butynyl)-1-methyl-8-(3-methylaminopiperidin-1-yl)-6-oxo-6,7-dihydro-1H-purin-2-yloxy]benzamide hydrochloride
https://huagongshe.com/reaction/501426
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Salicylamide | HCID 5147 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 8-(3-Aminopiperidin-1-yl)-7-(2-butynyl)-1-(2-cyanobenzyl)-6-oxo-6,7-dihydro-1H-purine-2-carbonitrile hydrochloride | HCID 23070665 | — |
| Reactant | t-butyl N-[1-[7-(2-butynyl)-2-chloro-1-methyl-6-oxo-6,7-dihydro-1H-purin-8-yl]piperidin-3-yl]-N-methylcarbamate | HCID 57472749 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 2-[7-(2-Butynyl)-1-methyl-8-(3-methylaminopiperidin-1-yl)-6-oxo-6,7-dihydro-1H-purin-2-yloxy]benzamide hydrochloride | HCID 23070829 | — |
Reaction Steps
A mixture consisting of 20 mg of t-butyl N-[1-[7-(2-butynyl)-2-chloro-1-methyl-6-oxo-6,7-dihydro-1H-purin-8-yl]piperidin-3-yl]-N-methylcarbamate, 20 mg of 2-hydroxybenzamide, 20 mg of anhydrous potassium carbonate, and 0.3 ml of N-methyl-2-pyrrolidone was stirred in an oil bath at 80° C. for 4 hours. Subsequent synthesis steps were carried out according to the same procedure as used in Examples 242(f) and (g) to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07772226B2 |
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| Source dataset | uspto-grants-2010_08 |
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| ORD ID | ord-982186c7eb6b49938322553db68f6991 |
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| Source note | uspto-grants-2010_08 |
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