HRID501426

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID5147

Salicylamide

C7H7NO2

HCID11430

Potassium Carbonate

CK2O3

结构：CC#CCn1c(N2CCCC(N)C2)nc2nc(C#N)n(Cc3ccccc3C#N)c(=O)c21.Cl

HCID23070665

未命名化合物

结构：CC#CCn1c(N2CCCC(N(C)C(=O)OC(C)(C)C)C2)nc2nc(Cl)n(C)c(=O)c21

HCID57472749

未命名化合物

PRODUCTS

生成物

结构：CC#CCn1c(N2CCCC(NC)C2)nc2nc(Oc3ccccc3C(N)=O)n(C)c(=O)c21.Cl

HCID23070829

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID13387

N-Methyl-2-pyrrolidone

C5H9NO

CONDITIONS

反应条件

温度: 80 °C

PROCEDURE

实验过程

A mixture consisting of 20 mg of t-butyl N-[1-[7-(2-butynyl)-2-chloro-1-methyl-6-oxo-6,7-dihydro-1H-purin-8-yl]piperidin-3-yl]-N-methylcarbamate, 20 mg of 2-hydroxybenzamide, 20 mg of anhydrous potassium carbonate, and 0.3 ml of N-methyl-2-pyrrolidone was stirred in an oil bath at 80° C. for 4 hours. Subsequent synthesis steps were carried out according to the same procedure as used in Examples 242(f) and (g) to give the title compound.

WORKUP

后处理

customSubsequent synthesis steps

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-982186c7eb6b49938322553db68f6991
来源数据集: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07772226B2
来源说明: uspto-grants-2010_08

反应 SMILES

[CH2:1]([N:5]1[C:13]2[C:12](=[O:14])[N:11]([CH3:15])[C:10]([Cl:16])=[N:9][C:8]=2[N:7]=[C:6]1[N:17]1[CH2:22][CH2:21][CH2:20][CH:19]([N:23]([CH3:31])C(=O)OC(C)(C)C)[CH2:18]1)[C:2]#[C:3][CH3:4].[OH:32][C:33]1[CH:41]=[CH:40][CH:39]=[CH:38][C:34]=1[C:35]([NH2:37])=[O:36].C(=O)([O-])[O-].[K+].[K+].Cl.NC1CCCN(C2N(CC#CC)C3C(=O)N(CC4C=CC=CC=4C#N)C(C#N)=NC=3N=2)C1>CN1CCCC1=O>[ClH:16].[CH2:1]([N:5]1[C:13]2[C:12](=[O:14])[N:11]([CH3:15])[C:10]([O:32][C:33]3[CH:41]=[CH:40][CH:39]=[CH:38][C:34]=3[C:35]([NH2:37])=[O:36])=[N:9][C:8]=2[N:7]=[C:6]1[N:17]1[CH2:22][CH2:21][CH2:20][CH:19]([NH:23][CH3:31])[CH2:18]1)[C:2]#[C:3][CH3:4]