tert-butyl N-(pyrrolidin-3-yl)carbamate → 8-(3-Aminopyrrolidin-1-yl)-7-(2-butynyl)-1-methyl-6-oxo-6,7-dihydro-1H-purine-2-carbonitrile hydrochloride

HRID 501427Notes

Reaction equation

HRID 501427 reaction equation
N1CCC(NC(=O)OC(C)(C)C)C1.CN(C1CCCNC1)C(=O)OC(C)(C)C.[ClH:29].[CH2:30]([N:34]1[C:42]2[C:41](=[O:43])[N:40]([CH3:44])[C:39]([C:45]#[N:46])=[N:38][C:37]=2[N:36]=[C:35]1[N:47]1C[CH2:51][CH2:50][CH:49]([NH:53]C)[CH2:48]1)[C:31]#[C:32][CH3:33]>>[ClH:29].[NH2:53][CH:49]1[CH2:50][CH2:51][N:47]([C:35]2[N:34]([CH2:30][C:31]#[C:32][CH3:33])[C:42]3[C:41](=[O:43])[N:40]([CH3:44])[C:39]([C:45]#[N:46])=[N:38][C:37]=3[N:36]=2)[CH2:48]1

Participants

4

Reactant 3

HCID 2757234tert-butyl N-(pyrrolidin-3-yl)carbamateHCID 22449166tert-butyl N-methyl-N-(piperidin-3-yl)carbamateHCID 230706617-(2-Butynyl)-1-methyl-8-(3-methylaminopiperidin-1-yl)-6-oxo-6,7-dihydro-1H-purine-2-carbonitrile hydrochloride

Product 1

HCID 230709778-(3-Aminopyrrolidin-1-yl)-7-(2-butynyl)-1-methyl-6-oxo-6,7-dihydro-1H-purine-2-carbonitrile hydrochloride

Procedure

In Example 254, the title compound was synthesized by using t-butyl pyrrolidin-3-ylcarbamate, instead of t-butyl N-methyl-N-(piperidin-3-yl)carbamate, according to the method described in Examples 254(b), (c), and (d).

Sources & evidence

ORD record
ord-8f086cbd7dfe43ac9c9c40359444e7bd
Source dataset
uspto-grants-2010_08
Patent number
US07772226B2

Reaction notes

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