HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-butyl N-(pyrrolidin-3-yl)carbamate → 8-(3-Aminopyrrolidin-1-yl)-7-(2-butynyl)-1-methyl-6-oxo-6,7-dihydro-1H-purine-2-carbonitrile hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-butyl N-(pyrrolidin-3-yl)carbamate | HCID 2757234 | — |
| Reactant | tert-butyl N-methyl-N-(piperidin-3-yl)carbamate | HCID 22449166 | — |
| Reactant | 7-(2-Butynyl)-1-methyl-8-(3-methylaminopiperidin-1-yl)-6-oxo-6,7-dihydro-1H-purine-2-carbonitrile hydrochloride | HCID 23070661 | — |
| Product | 8-(3-Aminopyrrolidin-1-yl)-7-(2-butynyl)-1-methyl-6-oxo-6,7-dihydro-1H-purine-2-carbonitrile hydrochloride | HCID 23070977 | — |
Reaction Steps
In Example 254, the title compound was synthesized by using t-butyl pyrrolidin-3-ylcarbamate, instead of t-butyl N-methyl-N-(piperidin-3-yl)carbamate, according to the method described in Examples 254(b), (c), and (d).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07772226B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-8f086cbd7dfe43ac9c9c40359444e7bd |
| Source note | uspto-grants-2010_08 |