反应详情

40 ml of allylamine was added to a 400 ml ethanol solution of 18.0 g of 4-ethoxy-3-nitropyridine hydrochloride, and the mixture was heated under reflux for 8 hours. The reaction solution was concentrated under reduced pressure. The residue was purified by silica gel column chromatography. Thus, 13.6 g of the title compound was obtained from the fraction eluted with ethyl acetate-hexane (1:1).

1. temperaturethe mixture was heated
2. temperatureunder reflux for 8 hours
3. concentrationThe reaction solution was concentrated under reduced pressure
4. customThe residue was purified by silica gel column chromatography