反应详情

温度

50 °C

To a solution of 2-[5-chloro-2-[2-(1-naphthyl) propanoylamino]phenyl methyl]benzoic acid methyl ester (440 mg; prepared in Example 1.) in methanol-dioxane (1:1; 8 ml) was added 2 mol/L aqueous solution of sodium hydroxide (3 ml) and the mixture was stirred for 3 hours at 50° C. The solution was acidified with hydrochloric acid and was extracted with ethyl acetate. The organic layer was washed with water and a saturated aqueous solution of sodium chloride, dried and concentrated to give a crude crystal. It was washed with ethyl acetate-hexane to give the title compound (342 mg; white powder) having the following physical data.

1. extractionwas extracted with ethyl acetate
2. washThe organic layer was washed with water
3. dry with materiala saturated aqueous solution of sodium chloride, dried
4. concentrationconcentrated
5. customto give a crude crystal
6. washIt was washed with ethyl acetate-hexane